Some discomfort from insertion may occur at first but with repeated use, administration will become much easier. Urinating right before administration to moisten the urethra is an important first step to reduce your chances of discomfort.

Sexual activity can begin immediately. However, lying down on your back right after insertion is not recommended. This position reduces blood flow to the penis and can reduce the erection. Sitting, standing or walking for about 10 minutes after insertion will encourage a more successful erection. This time has also been used by patients to include foreplay while assuming a different position.

An erection should be achieved withing 5-10 minutes after insertion and last approximately 30 to 60 minutes. Erection duration varies from patient to patient.

Intraurethral suppositories will produce a reliable erection for intercourse but may not create an erection felt exactly as in your past experiences. Mild pain and aching in the penis or groin area have been reported by some patients. It is normal for your penis to feel full, warm, and slightly sensitive even after the erection is over. These after-effects may last a few hours.

It is possible your erection may continue after orgasm. Applying ice packs alternatively to each inner thigh for at most 10 minutes at a time can shorten the duration of the erection. Call your doctor if you have an erection lasting more than 4 hours.

Most side effects are minor and include burning or aching in the penis and groin. Even rarer side effects include dizziness, light-headedness, fainting, rapid pulse, or swelling of the leg veins. If you feel light-headed or experience a rapid pulse, lie down and raise your legs. If the symptoms do not resolve, call your doctor.

It is recommended to store the intraurethral suppository in a refrigerator, but it can be kept at room temperature for up to 14 days. Do not expose the intraurethral suppository to extremely high temperatures (>86°F) or place in direct sunlight.